A wealth of evidence backs up the effectiveness of this brain supplement.
Written by Susan Parker | Updated on May 28, 2025
Reviewed by Susan Parker
Key Takeaways
PS supports brain health by enhancing communication.
PS supplementation improves cognitive function.
Natural PS production declines with age.
Frequently Asked Questions
Key Takeaways
PS supports brain health by enhancing communication.
PS supplementation improves cognitive function.
Natural PS production declines with age.
Frequently Asked Questions
“Age takes away all things, even the mind,” stated Virgil in 70 BC.
However, it is possible to maintain good mental function throughout life by making healthy food and lifestyle choices.
One important choice relates to a specific type of fat. Extensive research conducted over many decades has confirmed the cognitive benefits of this particular fat.
Findings from over 3000 research papers and 60 clinical trials conducted in the United States and globally demonstrate that phosphatidylserine (PS) strongly supports mental function and helps reduce the risk of cognitive decline and dementia.
About 60% of brain tissue consists of fats. Insufficient essential fats can lead to slowed mental processes and hinder optimal brain function. PS, a critical phospholipid, influences various brain functions.
Maintains membrane flexibility — Essential for keeping cell membranes pliable to facilitate the easy passage of proteins and nutrients.
Enhances communication — PS can increase cell surface receptors to improve message transmission efficiency and enhance communication.
Supports myelin—PS enriches the myelin sheath enveloping and insulating nerve cells. Myelin is crucial for swift electrical impulse conduction, resulting in fast processing speeds.
Replenishes acetylcholine—Lab studies indicate PS can help restore acetylcholine levels in aging brains. Decreased acetylcholine levels signify brain cell degeneration, and many memory and cognition drugs aim to boost acetylcholine.
PS also exhibits antioxidant properties, safeguards the brain against free radicals, enhances calcium uptake in brain synapses for efficient signal transmission, and reduces excess cortisol levels, the stress hormone. Elevated cortisol levels can have numerous adverse effects on the brain.
Over the years, numerous human studies on older individuals have been conducted. Seventeen of these studies were double-blind, comparing groups receiving PS with those on a placebo.
Consistent results from PS supplementation studies have shown enhancements in memory, learning, verbal skills, mood, focus, sociability, and daily activities. In a notable study involving 149 participants over 50 with age-related memory issues, improvements of 15% in learning and memory were observed in the PS group. The most impaired individuals showed the most improvement, and benefits persisted for a month post-supplementation cessation.
One study author concluded that PS appeared to reverse approximately twelve years of cognitive decline.
In a comprehensive study involving 494 patients aged 65 to 93 with moderate to severe cognitive decline, significant improvements in learning and memory scores were noted in the PS group compared to the placebo group over six months.
The body can produce PS, but this capability diminishes with age. Stress, consumption of refined fats and oils, and low-fat or vegetarian diets also lead to reduced PS levels.
Although PS is present in most foods, the quantities are generally minimal. Only a few foods contain measurable PS levels, with cow’s brain and organ meats like liver and kidneys being the highest sources. White beans are a notable vegetarian source.
PS is also available as a supplement, either alone or as part of a brain-supportive blend. This is the most effective way to maintain adequate PS levels, especially for older individuals.
offers a proven PS dosage in our blend – along with other beneficial ingredients.
Phosphatidylserine (PS), a vital phospholipid in the brain, plays a critical role in preserving cognitive function and reducing the risk of cognitive decline and dementia. Extensive research and clinical trials confirm that PS promotes brain health by maintaining flexible cell membranes, enhancing neuronal communication, supporting myelin integrity, and replenishing acetylcholine levels. PS also acts as an antioxidant, shields the brain from free radicals, and reduces cortisol levels that can harm brain function. Human studies demonstrate that PS supplementation enhances memory, learning, mood, and cognitive abilities, particularly in older adults. Given the decline in natural PS production with age, supplementation is recommended for optimal brain function.
Phosphatidylserine (PS) is a naturally occurring phospholipid crucial for brain function. It aids in maintaining cell membrane flexibility, enhancing intercellular communication, supporting myelin, and restoring acetylcholine levels essential for memory and learning.
Yes, studies indicate that PS supplementation can enhance memory, learning, mood, and daily functioning in older adults, particularly those facing age-related cognitive decline. Some studies suggest that PS may reverse cognitive aging by up to 12 years.
While PS is present in most foods, the quantities are generally minimal. Top sources include organ meats like liver and kidneys, cow’s brain, and white beans, though these are not commonly consumed in large amounts. Therefore, PS supplements are a practical choice for maintaining adequate levels.
The ideal PS dosage varies based on individual requirements and cognitive health. It is often recommended to take PS supplements as part of a comprehensive brain-health formula. For specific dosages, consult a healthcare professional, especially if you are older or experiencing cognitive challenges.
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