Neglected Nutrient Could Safeguard Your Heart
Written by Susan Parker | Updated on May 28, 2025
Reviewed by Susan Parker
Key Takeaways
PQQ essential for mitochondria energy supply
PQQ may help treat heart failure
PQQ beneficial for liver health
PQQ supports whole body health
Frequently Asked Questions
Key Takeaways
PQQ essential for mitochondria energy supply
PQQ may help treat heart failure
PQQ beneficial for liver health
PQQ supports whole body health
Frequently Asked Questions
When a metropolitan area experiences a blackout and all electrical devices cease to function, it becomes a significant event and a grave emergency.
Regrettably, the human body may face a similar predicament at times. Within the body, it is the mitochondria, the cellular organelles responsible for powering the cells, that may malfunction. This breakdown can lead to a crisis where the organs are deprived of energy.
The human body is equipped with various systems that work to safeguard the mitochondria from shutting down. Recent research reveals the importance of a vital nutrient that ensures the mitochondria's resilience against threats to their well-being. Some researchers even suggest that this nutrient should be classified as an essential vitamin due to its critical role in promoting the generation of new mitochondria to meet the body's energy requirements.
However, this crucial nutrient remains unfamiliar to most individuals.
Studies have demonstrated the essential role of pyrroloquinoline quinone (PQQ) in maintaining the energy flow supplied by mitochondria to every organ in the body.
For instance, experiments conducted in Asia have highlighted the significance of PQQ in supporting the strength of the heart muscle, suggesting its potential utility in treating heart failure.1
Researchers involved in these investigations emphasize that studies on heart function indicate that "mitochondria serve as the power source of the heart; yet, like an aged battery, the heart will eventually deplete (its mitochondria) in patients with chronic heart failure."
Here is where PQQ plays a critical role.
According to this study, PQQ acts as an antioxidant that prevents the excessive accumulation of free radicals (harmful oxidative byproducts) in mitochondria. Through this process, PQQ enters the mitochondria and eliminates destructive oxidative free radicals.
Moreover, PQQ can support the reproduction of mitochondria in the heart, enhancing the heart muscle's access to an increased energy supply that may counteract the slowdown leading to heart failure.
The researchers conclude that these benefits suggest PQQ could be beneficial in "preventing the occurrence of chronic heart failure."
Evidence is emerging that PQQ could play a role in the treatment and prevention of nonalcoholic fatty liver disease (NAFL).
Individuals who are overweight and experience blood sugar issues face an elevated risk of this liver condition, characterized by the accumulation of fat in the liver. NAFL can progress to cirrhosis, liver scarring, and life-threatening liver failure. Given the high prevalence of obesity in the United States, it is estimated that 100 million Americans have NAFL.
Additionally, this issue can be passed down to offspring. However, research at the University of Colorado suggests that PQQ might interrupt this intergenerational problem.2
Researcher Karen R. Jonscher, PhD, warns, "Nonalcoholic fatty liver disease is the most common liver ailment globally and affects approximately 35 percent of obese children in North America alone. Despite its increasing prevalence, there is currently no effective treatment available." She adds, "Our findings indicate that supplementation with PQQ, particularly during pregnancy and breastfeeding, could help slow the escalating epidemic of NAFLD in the next generation."
In addition to the Colorado study, other research suggests that PQQ could help prevent liver damage caused by high blood sugar in individuals with diabetes.3
Various studies have highlighted the potential of PQQ to enhance the well-being of almost every part of the human body, offering numerous benefits. Some of the noteworthy advantages include:
Several foods contain trace amounts of PQQ, including parsley, spinach, kiwi fruit, tomatoes, green tea, and carrots. If opting for supplements, it is advisable not to exceed the recommended dosage. There are concerns that excessive intake of PQQ could harm the kidneys.7 Therefore, it is crucial to follow the instructions on the packaging and use caution.
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