Recently Uncovered Organ Found Right in Front of Us All Along!
Written by Susan Parker | Updated on May 28, 2025
Reviewed by Susan Parker
Key Takeaways
New technology reveals hidden organ
Interstitium is largest organ
Interstitium functions as fluid network
Frequently Asked Questions
Key Takeaways
New technology reveals hidden organ
Interstitium is largest organ
Interstitium functions as fluid network
Frequently Asked Questions
I distinctly remember my initial exposure to the captivating pictures captured by the Hubble Space Telescope. Suddenly, we had the opportunity to witness stunning nebulas, remnants of supernova explosions, and distant galaxies. These cosmic marvels had always existed, but our technological constraints had hindered our ability to see them.
In a similar fashion, recent advancements in technology are transforming our comprehension of the human body. Despite thinking that we had thoroughly mapped out the human anatomy, a recent breakthrough has proven otherwise.
Physicians have recently discovered a previously unknown organ within the human body. Contrary to expectations, this organ is not small and inconspicuous—it is quite large.
This organ, referred to as the interstitium, holds around 20% of the body's fluid. The interstitium was accidentally identified by Dr. David Carr-Locke and Dr. Petros Benias of Mount Sinai-Beth Israel Medical Center in New York City while utilizing an advanced technology known as pCLE (probe-based confocal laser endomicroscopy).
Revolutionary technologies like pCLE, utilizing fiber-optics and low-power laser light, allow doctors to capture internal cellular images without the need for invasive tissue sampling and microscopic examination.
While examining a cancer patient's bile duct, Drs. Carr-Locke and Benias stumbled upon this unprecedented discovery.
Upon analyzing images from the cancer patient, they observed a network of fluid-filled cavities within a tissue layer. Subsequent examinations using pCLE in various patients and body regions revealed a consistent presence of this fluid-filled network, even in individuals without cancer.
It became apparent that this extensive network spreads throughout the entire body, evading previous detection due to the flattening of cavities when tissue samples are viewed under a microscope.
Imagine a layer of tiny bubble wrap beneath your skin's surface, as well as in muscle, lung, gut, and blood vessel linings. Instead of air-filled bubbles arranged symmetrically, these fluid-filled pockets are randomly dispersed, providing insight into the interstitium's location and structure.
The walls of the interstitium are made of collagen, previously thought to create a rigid boundary beneath the skin and around organs. However, it is now known that collagen contains fluid-filled pockets.
The collagen in the interstitium acts as a channel for fluid transport throughout the body.
Essentially, the interstitium aids in lymph fluid movement and nutrient distribution within tissues, as well as serving as a pathway for cancer metastasis.
Despite the wealth of information uncovered, much remains to be discovered about the interstitium. Scientists speculate on its role as a shock absorber and its potential for therapeutic applications in diseases like cancer, as it can assist in the distribution of various treatments.
This significant discovery has sparked discussions within the medical community regarding the interstitium's classification as an organ. While some remain doubtful, the majority of experts recognize its importance. Whether officially designated as an organ or not, the interstitium offers promising avenues for further research and innovation.
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