The Expensive Health Consequences of Low-Calorie Sweeteners
Written by Susan Parker | Updated on May 28, 2025
Reviewed by Susan Parker
Key Takeaways
Artificial sweeteners may lead to weight gain.
Artificial sweeteners hinder blood sugar control.
Sucralose raises risk of diabetes and metabolic syndrome.
Frequently Asked Questions
Key Takeaways
Artificial sweeteners may lead to weight gain.
Artificial sweeteners hinder blood sugar control.
Sucralose raises risk of diabetes and metabolic syndrome.
Frequently Asked Questions
Overview
One common critique of low or no-calorie artificial sweeteners is their lack of effectiveness in weight loss.
Ironically, they may even contribute to weight gain instead of weight loss.1
Moreover, despite claims of safety by the food industry, independent research indicates that artificial sweeteners can potentially lead to serious health issues.
Studies reveal that the substitution of sugar with artificial sweeteners in food and beverages can trigger a harmful process in the body that disrupts metabolism.
A recent study conducted at York University in Canada suggests that artificial sweeteners impede the body's ability to regulate blood sugar, especially in individuals who are overweight.
Researcher Jennifer Kuk warns that individuals with obesity who consume artificial sweeteners, particularly aspartame, may experience difficulties in managing glucose levels compared to those who do not use sugar substitutes.
In a study involving over 2,800 participants from the Third National Health and Nutrition Survey (NHANES III) who reported consuming aspartame or saccharin as artificial sweeteners or natural sugars, researchers assessed their blood sugar management using an oral glucose tolerance test, which measures the body's sugar absorption efficiency.
The findings of Dr. Kuk's research indicate that the issue originates in the digestive system, where artificial sweeteners are broken down by bacteria, leading to alterations in sugar metabolism.
Consumption of aspartame may result in ineffective sugar processing and an increased risk of elevated blood sugar levels, consequently heightening the risk of diabetes.
The study also sheds light on the impact of another artificial sweetener, saccharin.
Dr. Kuk explains that there were no adverse effects observed in individuals consuming saccharin or natural sugars.
Although saccharin may not interfere with the body's sugar metabolism or blood sugar balance, it was previously linked to cancer based on lab tests conducted in the late 1970s. However, subsequent research suggested that the mechanism through which saccharin induced cancer in laboratory animals does not apply to humans.
Current statements indicate that there is no definitive evidence supporting the link between saccharin and cancer in humans. Additionally, saccharin was removed from the U.S. National Toxicology Program's Report on Carcinogens in 2000.
These findings do not inspire confidence in saccharin, leading to a preference for natural sugar substitutes over artificial ones.
Research from George Washington University indicates that the consumption of sucralose, a sweetener produced through sugar chlorination and marketed as Splenda, may elevate the risk of developing metabolic syndrome.
Metabolic syndrome is characterized by excessive inflammatory fat around the waist, high blood pressure, elevated blood sugar, and an abundance of triglycerides in the blood. These factors increase the risks of obesity, diabetes, cancer, and double the likelihood of heart attack or stroke.
The study also reveals that sucralose independently heightens the risk of diabetes.
Furthermore, the research highlights the epigenetic effects of sucralose on genes, leading to increased fat accumulation within cells and promoting harmful oxidative inflammation, potentially fostering cancer growth and spread.3
There are various other reasons to avoid artificial sweeteners as research suggests they can:
It's essential to note that avoiding artificial sweeteners does not imply excessive sugar consumption as sugar poses its own health risks, notably an increased cancer risk from overconsumption.
The best approach is to limit the intake of cane sugar, high fructose corn syrup, and natural sugar substitutes while steering clear of artificial sweeteners entirely.
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